Dual Stimuli‐Responsive Polymeric Micelles Exhibiting “AND” Logic Gate for Controlled Release of Adriamycin

Authors:
Publisher website
Google Scholar
Abstract
A new controlled release polymer micelle was designed and synthesized based on the concept of the “AND” logic with two orthogonal molecular triggers, namely pH and reduction, for intracellular drug delivery. Specifically, a hydrazine functionalized PEO‐b‐PMAA block copolymer was used to attach adriamycin (ADR) through the formation of hydrazone, then the as‐prepared ADR‐conjugated block copolymer micelles could be crosslinked by dithiodiethanoic acid. ADR was found to release most efficiently under both the low pH and the reductive conditions. This smart device is therefore equipped with two triggers with the “AND” logic for the releasing action, which is suitable for more complicated physiological conditions because the “ON” state is only realized under the simultaneous presence of the dual signal stimuli. magnified image
Funding Information
  • National Science Foundation of China (20974023, 21034003 and 51073040)
  • National Science Foundation for Distinguished Young Scholars of China (50525310)
  • Shanghai Committee of Science and Technology, China (10XD1400500)

This publication has 23 references indexed in Scilit: