Inhibition of β‐amyloid toxicity by short peptides containing N‐methyl amino acids
- 1 March 2004
- journal article
- Published by Wiley in Chemical Biology & Drug Design
- Vol. 63 (3) , 324-328
Abstract
Abstract: Single N‐methyl amino acid‐containing peptides related to the central hydrophobic region β16–20 (Lys‐Leu‐Val‐Phe‐Phe) of the β‐amyloid protein are able to reduce the cytotoxicity of natural β1–42 in PC12 cell cultures. N‐methyl phenylalanine analogs yield statistically significant increments in cell viability (Student's t‐test < 0.01%) and are nontoxic in the same assay. These promising results indicate that these peptide molecules could be a starting point for the development of potential therapeutic compounds for the treatment of Alzheimer's disease.Keywords
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