PREDISPOSITION TO INFECTION FOLLOWING HEMORRHAGIC-SHOCK

Authors:
  • BEB C Esrig
    B C Esrig
  • LFL Frazee
    L Frazee
  • SSS F Stephenson
    S F Stephenson
  • HPH C Polk
    H C Polk
  • RFR L Fulton
    R L Fulton
  • CJC E Jones
    C E Jones
Google Scholar
  • 1 January 1977
    • journal article
    • research article
    • Vol. 144  (6) , 915-917
    • PMID:324005
Abstract
Subsequent life threatening gram-negative infection in patients successfully resuscitated from hemorrhagic shock is becoming increasingly common. Following hemorrhagic shock and resuscitation, Sprague-Dawley rats were given Escherichia coli i.p. to simulate the clinical setting in which peritoneal contamination and hypovolemic shock occur concurrently. A sublethal dosage of bacteria resulted in a 100% mortality. Hemorrhagic shock, even when treated promptly and effectively, may predispose to infection.