A 32-Year Prospective Study of Change in Body Weight and Incident Dementia
Authors:
- Robert StewartRobert Stewart
- Kamal MasakiKMKamal Masaki
- Qian-Li XueQXQian-Li Xue
- Rita PeilaRPRita Peila
- Helen PetrovitchHPHelen Petrovitch
- Lon R. WhiteLWLon R. White
- Lenore J. LaunerLenore J. Launer
Open Access
- 1 January 2005
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 62 (1) , 55-60
Abstract
Weight loss in old age is common and may be related to subclinical or clinical disease. It has long been observed that weight loss is common in Alzheimer disease (AD), but this has been documented in people who already have dementia.1-3 In AD cases, weight loss may be due to a variety of factors, including difficulties with maintaining nutritional intake and increased energy expenditure.4,5 However, neurodegenerative processes that begin before a clinical diagnosis is made may also be a primary cause of weight loss.6,7 Findings from some studies suggest that weight loss may actually start in the preclinical period of dementia.8,9 This weight loss may have important prognostic value.Keywords
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