Increased Preoperative Collection of Autologous Blood with Recombinant Human Erythropoietin Therapy

Authors:
  • SRSeth Rudnick
    Seth Rudnick
  • TPThomas H. Price
    Thomas H. Price
  • SBSamir K. Ballas
    Samir K. Ballas
  • MCMyra L. Collins
    Myra L. Collins
  • JCJames P. Crowley
    James P. Crowley
  • MKMartin Kosmin
    Martin Kosmin
  • MKMargot S. Kruskall
    Margot S. Kruskall
  • BLBruce A. Lenes
    Bruce A. Lenes
  • JMJay E. Menitove
    Jay E. Menitove
  • LSLeslie E. Silberstein
    Leslie E. Silberstein
  • KSKenneth J. Smith
    Kenneth J. Smith
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Abstract
To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before surgery, we conducted a randomized, controlled trial of erythropoietin in 47 adults scheduled for elective orthopedic procedures. The patients received either erythropoietin (600 units per kilogram of body weight) or placebo intravenously twice a week for 21 days, during which time up to 6 units of blood was collected. Patients were excluded from donation when their hematocrit values were less than 34 percent. All patients received iron sulfate (325 mg orally three times daily).

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