Quantification of Cerebral Glucose Concentrations via Detection of the H1‐α‐Glucose Peak in 1H MRS at 7 T

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Abstract
Background: Sensitive detection and quantification of cerebral glucose is desired.Purpose: To quantify cerebral glucose by detecting the H1‐α‐glucose peak at 5.23 ppm in 1H magnetic resonance spectroscopy at 7 T.Study Type: Prospective.Subjects: Twenty‐eight non‐fasted healthy subjects (aged 20–28 years).Field Strength/Sequence: Short echo time stimulated echo acquisition mode (short‐TE STEAM) and semi‐localized by adiabatic selective refocusing (semi‐LASER) at 7 T.Assessment: Single voxel spectra were obtained from the posterior cingulate cortex (27‐mL) using a 32‐channel head coil. The H1‐α‐glucose peak in the spectrum with retrospective removal of the residual water peak was fitted using LCModel with a glucose basis set of only the H1‐α‐glucose peak. Conventional spectral analysis was performed with a glucose basis set of a full spectral pattern of glucose, also. Fitting precision was evaluated with Cramér‐Rao lower bounds (CRLBs). The repeatability of glucose quantification via the semi‐LASER sequence was tested.Statistical Tests: Paired or Welch's t‐test were used for normally distributed values. A P value of P < 0.001). The conventional analysis overfitted the H1‐α‐glucose peak. The individual CVs of glucose quantification by detecting the H1‐α‐glucose peak were smaller than the corresponding CRLBs.Data Conclusion: Cerebral glucose concentration is quantitated to be 1.07 mM by detecting the H1‐α‐glucose peak in the semi‐LASER spectra. Despite requiring long scan times, detecting the H1‐α‐glucose peak allows true glucose quantification free from the influence of overlapping taurine and macromolecule signals.Evidence Level: 2Technical Efficacy Stage: 1

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