Gastrointestinal and Cardiovascular Risk of NonsteroidalAnti-inflammatory Drugs
Open Access
- 20 November 2011
- journal article
- Published by Oman Medical Journal in Oman Medical Journal
- Vol. 26 (6) , 385-391
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) confer a gastrointestinal (GI) side effect profile and concerns regarding adverse cardiovascular effects have emerged associated with considerable morbidity and mortality. NSAIDs are highly effective in treating pain and inflammation, but it is well recognized that these agents are associated with substantial gastrointestinal toxicity. Cyclo-oxygenase-2 inhibitors may also reduce the risk for gastrointestinal events, although they may increase cardiovascular adverse events. The selection of an appropriate analgesic or anti-inflammatory agent with or without gastroprotective therapy should be individualized.Keywords
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