Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature

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Abstract
Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with beta-thalassemia major (beta-TM). The most common skin disorders in patients with beta-TM are xerosis, urticaria, pseudoxanthoma, hyperpigmentation, leg ulcers and small-vessel vasculitis. Necrobiosis lipoidica has only been occasionally reported in patients with beta-TM. Herein, we present a female with beta-TM and NL. Furthermore, a brief review of the literature was performed.

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