Synthesis and Evaluation of Polyhydroxylated Near-Infrared Carbocyanine Molecular Probes
Authors:
- 15 May 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (12) , 2067-2070
Abstract
A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.Keywords
This publication has 12 references indexed in Scilit:
- High Efficiency Synthesis of a Bioconjugatable Near-Infrared FluorochromeBioconjugate Chemistry, 2003
- Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancementProceedings of the National Academy of Sciences, 2000
- Spectral characterization of a novel near-infrared cyanine dye: a study of its complexation with metal ionsTalanta, 1998
- Photophysics of Cyanine Dyes: Subnanosecond Relaxation Dynamics in Monomers, Dimers, and H- and J-Aggregates in SolutionThe Journal of Physical Chemistry B, 1997
- Synthesis of novel near‐infrared cyanine dyes for metal ion determinationJournal of Heterocyclic Chemistry, 1996
- A New Method for the Synthesis of Heptamethine Cyanine Dyes: Synthesis of New Near-Infrared Fluorescent LabelsThe Journal of Organic Chemistry, 1995
- Cyanine dye labeling reagents: Sulfoindocyanine succinimidyl estersBioconjugate Chemistry, 1993
- Enantioselective cation binding with a functionalized podand ionophoreThe Journal of Organic Chemistry, 1992
- J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potentialBiochemistry, 1991
- Stable heptamethine pyrylium dyes that absorb in the infraredThe Journal of Organic Chemistry, 1977