Guidelines for Pattern Recognition Using Differential Receptors and Indicator Displacement Assays
Authors:
- 21 May 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 74 (12) , 4479-4489
Abstract
A colorimetric sensor array consisting of designed receptors and metal salts was utilized for discrimination of structurally similar carboxylic acid analytes (25−31). For the discrimination, the receptors do not need to have a 1:1 guest−receptor binding stoichiometry. More than 1:1 stoichiometry, such as 1:2 or 2:1, affords useful information for the discrimination. The importance of data preselection and data preprocessing methods prior to principal component analysis is discussed. These methods change a score plot of principal components in a manner that enhances discrimination. Using the higher order stoichiometry, and the preselection as well as preprocessing discussed herein, we found that an addition of only one designed receptor to an array of metal salts can discriminate the structurally similar analytes.Keywords
This publication has 65 references indexed in Scilit:
- A Differential Array of Metalated Synthetic Receptors for the Analysis of Tripeptide MixturesJournal of the American Chemical Society, 2005
- An Organometallic Chemosensor for the Sequence‐Selective Detection of Histidine‐ and Methionine‐Containing Peptides in Water at Neutral pHAngewandte Chemie International Edition, 2004
- Threshold Detection Using Indicator-Displacement Assays: An Application in the Analysis of Malate in Pinot Noir GrapesJournal of the American Chemical Society, 2004
- Coordinative and electrostatic forces in action: from the design of differential chromogenic anion sensors to selective carboxylate recognitionChemical Communications, 2004
- 2,6-Di(pyrimidin-4-yl)pyridine Ligands with Nitrogen-Containing Auxiliaries: The Formation of Functionalized Molecular Clefts upon Metal CoordinationInorganic Chemistry, 2003
- C3v Symmetric Receptors Show High Selectivity and High Affinity for PhosphateJournal of the American Chemical Society, 2003
- Designing the Selectivity of the Fluorescent Detection of Amino Acids: A Chemosensing Ensemble for HistidineJournal of the American Chemical Society, 2002
- Fluorometric detection of fluoride ion by ligand exchange reaction with 3-hydroxyflavone coordinated to a zirconium(iv)–EDTA complexJournal of the Chemical Society, Perkin Transactions 2, 2002
- An Enzyme Assay Using pMAngewandte Chemie International Edition, 2001
- On-line monitoring of a cultivation using an electronic noseAnalytica Chimica Acta, 1998