NT-ProBNP Correlates with Right Heart Haemodynamic Parameters and Volumes in Patients with Atrial Septal Defects
Authors:
- 11 May 2007
- journal article
- Published by Oxford University Press (OUP) in European Journal of Heart Failure
- Vol. 9 (6-7) , 660-666
Abstract
Background: To investigate the role of N-terminal pro-BNP (NT-proBNP) for the estimation of right heart failure and pulmonary pressure in patients with atrial septal defects (ASD) before and after percutaneous defect closure. Methods: We performed correlation analysis for NT-proBNP and right ventricular systolic pressure (RVSP) as well as right ventricular enddiastolic and endsystolic volume (RVEDV, RVESV) determined by cardiac magnetic resonance imaging (MRI) before and up to one year following ASD closure. Additionally NT-proBNP concentrations were correlated with right atrial (RA) and RV enddiastolic pressure (RVEDP), ASD size and interatrial left-to-right shunt. Results: Baseline RVSP was 33±8 mmHg, which decreased significantly during follow-up. Initially, NT-proBNP levels were 240±93 pg/ml. After closure, a reduction to 1167±62 pg/ml was obvious (p<0.01). Baseline MRI showed enlarged RV volumes in all individuals. At six and twelve months follow-up a significant reduction of RVEDV and RVESV was apparent. A positive correlation was noted between RV volumes and NT-proBNP (r=0.65, p<0.05). Furthermore RA pressure, RVEDP, RVSP and left-to-right shunt significantly correlated to peptide levels. No correlation was seen between ASD size and NT-proBNP. Conclusion: NT-proBNP correlates to right ventricular dilatation, pulmonary pressure and left-to-right shunt in volume load of the right heart caused by an underlying ASD.Keywords
This publication has 30 references indexed in Scilit:
- Evaluation of Exercise Capacity with Cardiopulmonary Exercise Testing and Type B Natriuretic Peptide Concentrations in Adult Patients with Patent Atrial Septal DefectCardiology, 2006
- What is the normal range for N-terminal pro-brain natriuretic peptide? How well does this normal range screen for cardiovascular disease?European Heart Journal, 2005
- Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady‐state free precession imaging sequencesJournal of Magnetic Resonance Imaging, 2003
- Athlete’s heartJACC, 2002
- Improvement in Exercise Capacity in Asymptomatic and Mildly Symptomatic Adults After Atrial Septal Defect Percutaneous ClosureCirculation, 2002
- Neurohormonal Activation and the Chronic Heart Failure Syndrome in Adults With Congenital Heart DiseaseCirculation, 2002
- Quantitative evaluation of the changes in plasma concentrations of cardiac natriuretic peptide before and after transcatheter closure of atrial septal defectActa Paediatrica, 2002
- Do patients over 40 years of age benefit from closure of an atrial septal defect?Heart, 2001
- Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levelsJACC, 1995
- Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation.Circulation, 1984