Syntheses, analgetic activity and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives

Authors:
  • NYN Yokoyama
    N Yokoyama
  • PAP I Almaula
    P I Almaula
  • FBF B Block
    F B Block
  • FGF R Granat
    F R Granat
  • NGN Gottfried
    N Gottfried
  • RHR T Hill
    R T Hill
  • EME H McMahon
    E H McMahon
  • WMW F Munch
    W F Munch
  • HRH Rachlin
    H Rachlin
  • JSJ K Saelens
    J K Saelens
  • MSM G Siegel
    M G Siegel
  • HTH C Tomaselli
    H C Tomaselli
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Abstract
Observations made during the Stevens'' rearrangement of 1-benzyl-1-methyl-.DELTA.3-piperidinium salt derivatives under various conditions are discussed. The absolute configuration of the 9-demethyl series and the 2''-deoxy series is established. A convenient synthesis of 3H-labeled phenols using 3H3PO4 is described, as well as the preparation of 14C-labeled compounds by conventional methods. Analgetic activity and physical dependence was examined in mice.