Visible Light-Mediated Synthesis of Chalcogen-Decorated 2,3-Dihydrobenzofurans in the Absence of Photocatalyst and Oxidants

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Abstract
A sustainable visible light-promoted protocol for preparing selenium- and sulfur-decorated 2,3-dihydrobenzofurans from 2-allylphenols and diorganyl dichalcogenides is reported. The reaction proceeds under blue LEDs irradiation (Kessil PR160L, λmax = 440 nm) under mild conditions, in the absence of photocatalysts or oxidants, in accordance with the green chemistry principles. Eighteen derivatives were obtained, covering electron-rich, electron-deficient, and polycyclic systems, with yields from 20% to 96%. The method is operationally simple, scalable, and tolerant to diverse aryl substituents, although the presence of electron-withdrawing groups reduces its efficiency. This approach offers an ecofriendly alternative to conventional oxidative or photocatalyst-mediated strategies to prepare the target molecules, opening new opportunities for advancing organoselenium chemistry and exploring its potential in organic synthesis.
Funding Information
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (401355/2025-0)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (405655/2023-1)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (422645/2021-4)
  • Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (23/2551-0000800-9)
  • Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (PqG 24/2551-0001565-5)
  • Financiadora de Estudos e Projetos
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)

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