Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study
Authors:
- Oded LewinsonOLOded Lewinson
- Etana PadanEPEtana Padan
- Eitan BibiEBEitan Bibi
- 10 June 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 3 (7) , 566-572
Abstract
Drug and multidrug resistance have greatly compromised the compounds that were once the mainstays of antibiotic therapy. This resistance often persists despite reductions in the use of antibiotics, indicating that the proteins encoded by antibiotic-resistance genes have alternative physiological roles that can foster such persistence in the absence of selective pressure by antibiotics. The recent observations that Tet(L), a tetracycline-efflux transporter, and MdfA, a multidrug-efflux transporter, both confer alkali tolerance offer a striking case study in support of this hypothesis.Keywords
This publication has 76 references indexed in Scilit:
- Antibacterial resistance worldwide: causes, challenges and responsesNature Medicine, 2004
- The 'evolvability' of promiscuous protein functionsNature Genetics, 2004
- Antibacterial drug discovery: is it all downhill from here?Clinical Microbiology and Infection, 2004
- Antibiotics2003
- Bacterial Resistance: Origins, Epidemiology, and ImpactClinical Infectious Diseases, 2003
- Antibiotic resistance in the absence of selective pressureInternational Journal of Antimicrobial Agents, 2001
- The impact of antibiotic use on resistance development and persistenceDrug Resistance Updates, 2000
- VanX, a bacterial d -alanyl- d -alanine dipeptidase: Resistance, immunity, or survival function?Proceedings of the National Academy of Sciences, 1999
- Evolutionary origins of multidrug and drug-specific efflux pumps in bacteriaThe FASEB Journal, 1998
- Natural functions of bacterial multidrug transportersTrends in Microbiology, 1997