Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults
Open Access
- 1 July 2017
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Neurology
- Vol. 74 (7) , 830-838
Abstract
The advent of in vivo amyloid imaging has resulted in a corpus of cross-sectional data that indicate that cognitively normal older adults vary considerably in their magnitude of amyloid deposition. Those in the higher range of amyloid burden often demonstrate deficits in episodic memory,1-5 a hallmark of Alzheimer disease (AD), and other domains of cognition.4,6-9 Contemporary models of AD posit that healthy individuals harboring elevated amyloid pathology are in a preclinical stage of AD and on a trajectory toward developing dementia.10,11Keywords
This publication has 37 references indexed in Scilit:
- β-Amyloid burden in healthy agingNeurology, 2012
- Not quite PIB-positive, not quite PIB-negative: Slight PIB elevations in elderly normal control subjects are biologically relevantNeuroImage, 2012
- β-Amyloid affects frontal and posterior brain networks in normal agingNeuroImage, 2011
- Cognition, reserve, and amyloid deposition in normal agingAnnals of Neurology, 2010
- Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [ 11 C]PiBNeurology, 2010
- Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascadeThe Lancet Neurology, 2010
- Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjectsBrain, 2008
- Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the ElderlyArchives of Neurology, 2008
- Cortical Surface-Based AnalysisNeuroImage, 1999
- The hopkins verbal learning test: Development of a new memory test with six equivalent formsThe Clinical Neuropsychologist, 1991