Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles
- 3 October 2017
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Biomaterials Science
- Vol. 5 (12) , 2393-2397
Abstract
Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine–glycine–aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αvβ3 integrin-expressing tumors.Keywords
Funding Information
- Science and Technology Commission of Shanghai Municipality (15520711400, 17540712000)
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