Association between Cognitive Impairment and Gait Disturbance in Patients with Idiopathic Normal Pressure Hydrocephalus
Authors:
- Hiroaki KazuiHKHiroaki Kazui
- Atsushi OginoAOAtsushi Ogino
- Masatsune IshikawaMIMasatsune Ishikawa
- Hiroji MiyakeHMHiroji Miyake
- Hiromasa TokunagaHTHiromasa Tokunaga
- Yoshitaka IkejiriYIYoshitaka Ikejiri
- Masatoshi TakedaMTMasatoshi Takeda
- 1 August 2005
- journal article
- clinical trial
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 20 (2-3) , 71-76
Abstract
We compared the scores of the Frontal Assessment Battery (FAB), initial fluency subtest, category fluency subtest and subtests of the Mini-Mental State Examination (MMSE) between patients with idiopathic normal pressure hydrocephalus (iNPH) and age-, sex- and MMSE-matched patients with Alzheimer’s disease (AD). In patients with iNPH, the time and number of steps required to go and come back a 10-meter distance were measured (Walking test) and the associations between the scores of the cognitive tests and the performance of the Walking test were evaluated. The scores of the FAB and initial fluency subtest in patients with iNPH were significantly lower than those in patients with AD. The scores of the FAB, initial fluency subtest and serial 7 subtest of the MMSE significantly correlated with the two scores of the Walking test in patients with iNPH. The present results indicate that frontal lobe functions were impaired in patients with iNPH and that cognitive impairment was closely associated with gait disturbance in patients with iNPH.Keywords
This publication has 33 references indexed in Scilit:
- Cognitive Impairment Decreases Postural Control During Dual Tasks in Geriatric Patients with a History of Severe FallsJournal of the American Geriatrics Society, 2003
- Developmental aspects of language processing: fMRI of verbal fluency in children and adultsHuman Brain Mapping, 2003
- Relationship between regional cerebral blood flow and verbal fluency in Alzheimer's diseasePsychiatry and Clinical Neurosciences, 2001
- Comparative analysis of the gait disorder of normal pressure hydrocephalus and Parkinson's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2001
- A comparison of rCBF patterns during letter and semantic fluency.Neuropsychology, 2000
- Motor Disturbances in Normal-Pressure HydrocephalusArchives of Neurology, 1986
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- A Modified Card Sorting Test Sensitive to Frontal Lobe DefectsCortex, 1976
- “Mini-mental state”Journal of Psychiatric Research, 1975
- The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressureJournal of the Neurological Sciences, 1965