The Internet of Things (IoT), defined as the networking capability that allows information to be sent to and received from objects and devices on the Internet (Merriam-Webster Dictionary 2021), is rapidly changing how and where care is provided. Advances in sensor technology, wired and wireless networks and commercial acceptance of standards are accelerating medical health systems adoption of the IoT. Data captured by sensors on medical devices and sent via networks to large databases in the Cloud are being analyzed to discover new knowledge as well as to create artificial intelligence for a variety of clinical activities. The IoT is enabling the transformation of health systems from a hospital-centric model to patient-centered care through its capacity to provide access anywhere along the continuum of care. Nurses play a key role in this transformation as they mediate information flow between patients and providers and their various levels of care. This chapter discusses the technological building blocks of the IoT and how it provides value through the ‘information value loop.’ The chapter also provides examples of how nurses are utilizing the IoT in practice and how the IoT is transforming healthcare delivery system models of care.