Islet Cell Antibodies and Other Autoantibodies in South African Blacks and Indians with Insulin Dependent Diabetes Mellitus (IDDM)

Authors:
  • MOM. A. K. Omar
    M. A. K. Omar
  • GBG. Bottazzo
    G. Bottazzo
  • AAA. Asmal
    A. Asmal
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Abstract
The presence or absence of islet cell antibodies and other autoantibodies was determined in 47 African and 34 Indian patients with IDDM and 37 controls. Islet cell antibodies (ICA-IgG) were found in over a third of the patients and in only 2 controls. Complement fixing antibodies (ICA-Cf) were found in 10 % of patients, but in none of the controls. Persistence of ICA beyond 3 years was more frequent in Black compared to Indian patients. Parietal cell antibodies were found more often in patients (20 %) than controls (5 %) as were thyroid microsomal antibodies (11 % vs. 0 %). None of the patients or controls had adrenal antibodies.