Validation of an LC-MS/MS method to determine five immunosuppressants with deuterated internal standards including MPA
Open Access
- 11 January 2012
- journal article
- research article
- Published by Springer Nature in BMC Clinical Pharmacology
- Vol. 12 (1) , 2
Abstract
Therapeutic drug monitoring of immunosuppressive drugs in organ-transplanted patients is crucial to prevent intoxication or transplant rejection due to inadequate dosage. The commonly used immunoassays have been gradually undergoing replacement by mass spectrometry, since this physical method offers both a higher sensitivity and specificity. However, a switch should be carefully considered because it is a challenging procedure and needs to be thoroughly validated.Keywords
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