Anomalous Differences of Light Elements in Determining Precise Binding Modes of Ligands to Glycerol-3-Phosphate Dehydrogenase
Authors:
- Stephen SureshSSStephen Suresh
- Kevin J KennedyKKKevin J Kennedy
- 1 November 2002
- journal article
- Published by Elsevier in Chemistry & Biology
- Vol. 9 (11) , 1189-1197
Abstract
No abstract availableKeywords
This publication has 44 references indexed in Scilit:
- Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase of Trypanosomatidae via Structure-Based Drug DesignJournal of Medicinal Chemistry, 2001
- Adenosine Analogues as Inhibitors of Trypanosoma brucei Phosphoglycerate Kinase: Elucidation of a Novel Binding Mode for a 2-Amino-N6-Substituted AdenosineJournal of Medicinal Chemistry, 2000
- Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenaseProceedings of the National Academy of Sciences, 1999
- Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activationNature, 1997
- Crystal Structure of Glycosomal Glyceraldehyde-3-phosphate Dehydrogenase from Leishmania mexicana: Implications for Structure-Based Drug Design and a New Position for the Inorganic Phosphate Binding SiteBiochemistry, 1995
- Molecular Mechanisms and Therapeutic Approaches to the Treatment of African TrypanosomiasisAnnual Review of Pharmacology and Toxicology, 1995
- Structure-based drug design: progress, results and challengesStructure, 1994
- Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data.Proceedings of the National Academy of Sciences, 1993
- Structure of the complex between trypanosomal triosephosphate isomerase and N‐hydroxy‐4‐phosphono‐butanamide: Binding at the active site despite an “open” flexible loop conformationProtein Science, 1992
- Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerateJournal of Medicinal Chemistry, 1991