All-Trans-Retinoic Acid and Pseudotumor Cerebri

Authors:
  • SMS. Manfroi
    S. Manfroi
  • PTP. Tosi
    P. Tosi
  • GMG. Martinelli
    G. Martinelli

Abstract
Pseudotumor cerebri or idiopathic intracranial hypertension is a neurological syndrome characterized by signs and symptoms of intracranial hypertension without clinical and radiological evidence of infective or space occupying lesions. Iatrogenic factors are frequent; in particular, cases of Pseudotumor cerebri associated with all-trans-retinoic acid treatment in acute promyelocytic leukemia (APL) have been frequently described in pediatric patients. We review the literature and give diagnostic and therapeutic guidelines.

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