Ophthalmoplegic Migraine: Amelioration by Flufenamic acid, a Prostaglandin inhibitor

Authors:
  • JRJ.M. Rabey
    J.M. Rabey
  • YVY. Vardi
    Y. Vardi
  • DDD. Van Dyck
    D. Van Dyck
  • MSM. Streijler
    M. Streijler
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Abstract
It was recently suggested that prostaglandins' release (especially PGE1 and PGF2alpha) play a key role in the development of the migrainous attack. Based on this hypothesis a therapeutic trial with flufenamic acid (a prostaglandin inhibitor of the fenamates group) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine. We treated 25 migrainous attacks; in 22 of them the patients reported marked alleviation of the headaches and only in two occasions a partial third nerve palsy accompanied the attack.