Screening of Catalytically Active Microorganisms for the Synthesis of 6-Modified Purine Nucleosides
Authors:
- 1 June 2005
- journal article
- Published by Springer Nature in Biotechnology Letters
- Vol. 27 (11) , 759-763
Abstract
Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in␣microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus ATCC 12980 was the best for this purpose.Keywords
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