SIMPLIFIED DETECTION SYSTEM FOR NEURORECEPTOR STUDIES IN THE HUMAN-BRAIN

Authors:
  • ABAN BICE
    AN BICE
  • HWHN WAGNER
    HN WAGNER
  • JFJJ FROST
    JJ FROST
  • TNTK NATARAJAN
    TK NATARAJAN
  • MLMC LEE
    MC LEE
  • DWDF WONG
    DF WONG
  • RDRF DANNALS
    RF DANNALS
  • HRHT RAVERT
    HT RAVERT
  • AWAA WILSON
    AA WILSON
  • JLJM LINKS
    JM LINKS
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  • 1 February 1986
    • journal article
    • research article
    • Vol. 27  (2) , 184-191
    • PMID:3012020
Abstract
A simple, inexpensive dual-detector system has been developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.