On the use of [18F]DOPA as an imaging biomarker for transplanted islet mass
Authors:
- 29 October 2013
- journal article
- research article
- Published by Springer Nature in Annals of Nuclear Medicine
- Vol. 28 (1) , 47-52
Abstract
Islet transplantation is being developed as a potential cure for patients with type 1 diabetes. There is a need for non-invasive imaging techniques for the quantification of transplanted islets, as current transplantation sites are associated with a substantial loss of islet viability. The dopaminergic metabolic pathway is present in the islets; therefore, we propose Fluorine-18 labeled l-3,4-dihydroxyphenylalanine ([18F]DOPA) as a biomarker for transplanted islet mass.Keywords
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