Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution.

Author:
  • GKG Klein
    G Klein
Publisher website
Google Scholar
Abstract
Human B [bone marrow derived] cell lymphoma and murine T [thymus-derived] cell leukemia can be initiated by several agents. The role of cytogenetic changes in the subsequent neoplastic process is discussed. Initiation creates long-lived preneoplastic cells. In some respects, they are comparable to in vitro-transformed (immortalized) cell lines that maintain a diploid karyotype and are not tumorigenic in vivo. The development of a tumorigenic (autonomous) clone is dependent on additional changes at the genetic level. In human B and murine T cell lymphoma, there are characteristic nonrandom chromosomal changes. The 14q+ marker appears to play a key role in human B cell lymphomas. The reciprocal 8;14 translocation in Burkitt lymphoma is a specialized subclass within this category. In murine T cell leukemia, trisomy 15 is the predominant change. The clustering of these nonrandom changes to tumors derived from a certain cell type rather than to tumors induced by a given etiological agent has important implications for the understanding of the genetic control of cellular responsiveness to growth-regulating forces in vivo.

This publication has 72 references indexed in Scilit: