Brain Metabolism in Autism
Authors:
- Judith M. RumseyJRJudith M. Rumsey
- Ranjan DuaraRDRanjan Duara
- Cheryl GradyCGCheryl Grady
- Judith L. RapoportJRJudith L. Rapoport
- Richard A. MargolinRMRichard A. Margolin
- Stanley I. RapoportSRStanley I. Rapoport
- Neal R. CutlerNCNeal R. Cutler
- 1 May 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 42 (5) , 448-455
Abstract
• The cerebral metabolic rate for glucose was studied in ten men (x̄ age=26 years) with well-documented histories of infantile autism and in 15 age-matched normal male controls using positron emission tomography and (F-18) 2-fluoro-2-deoxy-D-glucose. Positron emission tomography was completed during rest, with reduced visual and auditory stimulation. While the autistic group as a whole showed significantly elevated glucose utilization in widespread regions of the brain, there was considerable overlap between the two groups. No brain region showed a reduced metabolic rate in the autistic group. Significantly more autistic, as compared with control, subjects showed extreme relative metabolic rates (ratios of regional metabolic rates to whole brain rates and asymmetries) in one or more brain regions.Keywords
This publication has 17 references indexed in Scilit:
- Disturbance of oxidative metabolism of glucose in recent human cerebral infarctsAnnals of Neurology, 1983
- CEREBRAL GLUCOSE UTILIZATION, AS MEASURED WITH POSITRON EMISSION TOMOGRAPHY IN 21 RESTING HEALTHY MEN BETWEEN THE AGES OF 21 AND 83 YEARSBrain, 1983
- Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of 18FDG and 13NH3Annals of Neurology, 1980
- Noninvasive determination of local cerebral metabolic rate of glucose in manAmerican Journal of Physiology-Endocrinology and Metabolism, 1980
- Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of methodAnnals of Neurology, 1979
- Incidence of minor physical anomaly in autismJournal of Autism and Developmental Disorders, 1977
- Hyperserotonemia and Amine Metabolites in Autistic and Retarded ChildrenArchives of General Psychiatry, 1977
- Neuropathologic aspects of psychosis in childrenJournal of Autism and Developmental Disorders, 1976
- Minor physical anomalies in normal, neurotic, learning disabled, and severely disturbed childrenJournal of Autism and Developmental Disorders, 1975
- Circulation and metabolism of the human brain in health and diseaseThe American Journal of Medicine, 1950