Topical Fluorouracil for Actinic Keratoses and Photoaging
Authors:
- Dana L. SachsDSDana L. Sachs
- Sewon KangSKSewon Kang
- Craig HammerbergCHCraig Hammerberg
- Yolanda HelfrichYHYolanda Helfrich
- Darius KarimipourDKDarius Karimipour
- Jeffrey OrringerJOJeffrey Orringer
- Timothy JohnsonTJTimothy Johnson
- Ted A. HamiltonTHTed A. Hamilton
- Gary FisherGFGary Fisher
- John J. VoorheesJVJohn J. Voorhees
Open Access
- 1 June 2009
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 145 (6) , 659-666
Abstract
Fluorouracil is an antimetabolite chemotherapeutic agent that inhibits the synthesis of thymine, a critical building block of DNA. Fluorouracil is preferentially incorporated into the DNA of cancers of the bone marrow, intestine, liver, and other tissues and leads to cell death. It is used systemically to treat cancers of the colon, head and neck, pancreas, and other organs.1-5Keywords
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