New Modalities and Aspects of Antiplatelet Therapy for Stroke Prevention
Authors:
- Shinichiro UchiyamaSUShinichiro Uchiyama
- Tomomi NakamuraTNTomomi Nakamura
- Masako YamazakiMYMasako Yamazaki
- Yumi KimuraYKYumi Kimura
- Makoto IwataMIMakoto Iwata
- 1 February 2006
- journal article
- Published by S. Karger AG in Cerebrovascular Diseases
- Vol. 21 (Suppl. 1) , 7-16
Abstract
Antiplatelet therapy is indicated for secondary prevention of ischaemic stroke. The first-line antiplatelet agent is aspirin. The effect of aspirin is, however, very limited, and this limited effect of aspirin is argued with termed ‘aspirin resistance’. Strategies against aspirin resistance may include alternative use of other antiplatelet agents, combination of aspirin with other antiplatelet agents and investigation into molecular targets to develop novel antiplatelet agents. Progress in antiplatelet therapy should be directed at further reducing the risk of ischaemic events including ischaemic stroke without increasing the risk of haemorrhagic events including haemorrhagic stroke.Keywords
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