Pharmacokinetics of digoxin in pregnancy
Authors:
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 25 (1) , 117-121
Abstract
Summary Digoxin-renal-clearance, creatinine-clearance, 24-h urine elimination of digoxin and serum digoxin were studied in 15 patients in the third trimester of pregnancy and 6 to 12 weeks post-partum. There was significant fall post-partum in the first three. There was also a significant fall post-partum in serum digoxin levels. This finding was unexpected, but may be due to heightened absorption exceeding increased elimination because of the physiological status in pregnancy.Keywords
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