Conserved and variable natural killer cell receptors: diverse approaches to viral infections
Authors:
Open Access
- 20 December 2018
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 156 (4) , 319-328
Abstract
Natural Killer (NK) cells are lymphocytes of the innate immune system with essential roles during viral infections. NK cell functions are mediated through a repertoire of non‐rearranging inhibitory and activating receptors that interact with MHC:peptide complexes on the surface of infected cells. Recent work studying the conserved CD94:NKG2A and variable KIR:MHC systems suggest that these two receptor families may have subtly different properties in terms of interactions with MHC class I bound peptides, and in recognition of down‐regulation of MHC class I. In this review we discuss how these properties generate diversity in the NK cell response to viruses.Keywords
Funding Information
- Departamento Administrativo de Ciencia, Tecnologia e Innovacion
- University of Southampton
- Newton Fund
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