Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus
Open Access
- 1 July 2011
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 49 (7) , 2680-2684
Abstract
Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype expression.Keywords
This publication has 22 references indexed in Scilit:
- An RpoB Mutation Confers Dual Heteroresistance to Daptomycin and Vancomycin in Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2010
- Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical ImplicationsClinical Microbiology Reviews, 2010
- Selection of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus by ImipenemAntimicrobial Agents and Chemotherapy, 2009
- The First Vancomycin-Intermediate Staphylococcus aureus Strains Isolated from Patients in ThailandJournal of Clinical Microbiology, 2009
- Genetic Diversity of Staphylocoagulase Genes (coa): Insight into the Evolution of Variable Chromosomal Virulence Factors in Staphylococcus aureusPLOS ONE, 2009
- Characterization of Methicillin-Resistant Staphylococcus aureus Isolates Collected in 2005 and 2006 from Patients with Invasive Disease: a Population-Based AnalysisJournal of Clinical Microbiology, 2009
- Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2009
- Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2008
- Mutated Response Regulator graR Is Responsible for Phenotypic Conversion of Staphylococcus aureus from Heterogeneous Vancomycin-Intermediate Resistance to Vancomycin-Intermediate ResistanceAntimicrobial Agents and Chemotherapy, 2008
- Antimicrobial Susceptibility Patterns and Staphylococcal Cassette Chromosome mec Types of, as Well as Panton-Valentine Leukocidin Occurrence among, Methicillin-Resistant Staphylococcus aureus Isolates from Children and Adults in Middle TennesseeJournal of Clinical Microbiology, 2006