Sex steroid hormone secretion in the wall lizard Podarcis sicula testis: The involvement of VIP
- 9 September 2015
- journal article
- research article
- Published by Wiley in Journal of Experimental Zoology Part A: Ecological and Integrative Physiology
- Vol. 323 (10) , 714-721
Abstract
Vasoactive intestinal peptide (VIP) is a pleiotropic neuropeptide involved in different functions, including testosterone synthesis. Recently, we reported the presence of VIP in the testis of Podarcis sicula, throughout the reproductive cycle. Now, we investigated the effects of the VIP on steroidogenesis in significant periods of the Podarcis reproductive cycle: winter stasis, reproductive period, and summer stasis. Using VIP treatments in testis culture in absence or presence of receptors antagonists, we demonstrated for the first time that in P. sicula, VIP is involved not only in testosterone synthesis, as in mammals, but in 17β‐estradiol synthesis too. J. Exp. Zool. 323A: 714–721, 2015.Keywords
This publication has 29 references indexed in Scilit:
- Oestrogens and spermatogenesisPhilosophical Transactions of the Royal Society B: Biological Sciences, 2010
- Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the DiscoveryPharmacological Reviews, 2009
- VPAC and PAC receptors: From ligands to functionPharmacology & Therapeutics, 2009
- Lack of vasoactive intestinal peptide reduces testosterone levels and reproductive aging in mouse testisJournal of Endocrinology, 2007
- Participation of vasoactive intestinal polypeptide in ovarian steroids production during the rat estrous cycle and in the development of estradiol valerate-induced polycystic ovaryReproduction, 2007
- Neurotransmitters co-existing with VIP or PACAPPeptides, 2004
- The Origin and Function of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)/Glucagon SuperfamilyEndocrine Reviews, 2000
- Local Effect of PACAP and VIP on Testicular Function in Immature and Adult RatsPeptides, 1997
- Vasoactive Intestinal Peptide-Induced Expression of Cytochrome P450 Cholesterol Side-Chain Cleavage and 17α-Hydroxylase Enzyme Activity in Hen Granulosa Cells1Biology of Reproduction, 1994
- A Novel Hypothalamic Peptide, Pituitary Adenylate Cyclase Activating Peptide, Modulates Sertoli Cell Function in VitroBiology of Reproduction, 1992