Ryanodine and inositol triphosphate receptors modulate facilitation and tetanic depression at the frog neuromuscular junction
- 19 January 2015
- journal article
- basic and-translational-science
- Published by Wiley in Muscle & Nerve
- Vol. 52 (4) , 623-630
Abstract
Introduction: Short‐term plasticity of synaptic function is an important physiological control of transmitter release. Short‐term plasticity can be regulated by intracellular calcium released by ryanodine and inositol triphosphate (IP3) receptors, but the role of these receptors at the neuromuscular junction is understood incompletely.Methods: We measured short‐term plasticity of evoked endplate potential (EPP) amplitudes from frog neuromuscular junctions treated with ryanodine, 2‐aminoethoxydiphenylborane (2‐APB), or 1‐[6‐[[(17β)‐3‐methoxyestra‐1,3,5(10)‐trien‐17‐yl]amino]hexyl]‐1H‐pyrrole‐2,5‐dione (U‐ 73122).Results: Ryanodine decreases paired‐pulse facilitation for intervals Muscle Nerve52: 623–630, 2015Keywords
Funding Information
- Concelho Nacional de Desenvolvimento CientÃfico e Tecnológico (478663/2012-9)
This publication has 35 references indexed in Scilit:
- Nicotine Elicits Prolonged Calcium Signaling along Ventral Hippocampal AxonsPLOS ONE, 2013
- Endplate contributions to the safety factor for neuromuscular transmissionMuscle & Nerve, 2011
- Transient Upregulation of Postsynaptic IP3-Gated Ca Release Underlies Short-Term Potentiation of Metabotropic Glutamate Receptor 1 Signaling in Cerebellar Purkinje CellsJournal of Neuroscience, 2008
- Presynaptic Ryanodine Receptor-Activated Calmodulin Kinase II Increases Vesicle Mobility and Potentiates Neuropeptide ReleaseJournal of Neuroscience, 2007
- Extrusion of Ca2+ from mouse motor terminal mitochondria via a Na+–Ca2+ exchanger increases post‐tetanic evoked releaseThe Journal of Physiology, 2006
- Distinct Transmitter Release Properties Determine Differences in Short-Term Plasticity at Functional and Silent SynapsesJournal of Neurophysiology, 2006
- Short-Term Synaptic PlasticityAnnual Review of Physiology, 2002
- Functional Coupling of Ca2+ Channels to Ryanodine Receptors at Presynaptic TerminalsJournal of General Physiology, 2000
- Presynaptic effects of muscarine on ACh release at the frog neuromuscular junctionThe Journal of Physiology, 1999
- Transmitter release at frog end-plate loaded with a Ca2+-chelator, BAPTA: hypertonicity and erythrosin B augment the release independently of internal Ca2+Neuroscience Letters, 1988