Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A–T pair
- 27 August 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 3 (44) , 21352-21355
Abstract
A better than reported abasic duplex stabilization was achieved with the novel triazolylphenanthrene nucleoside TPhenBDo. The large surface area, polarizability and strong stacking propensity of triazolylphenanthrene play a major role in the thermal stabilization of the TPhenBDo–Φ duplex comparable to that of a natural A–T pair via a strong intercalative stacking interaction.Keywords
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