Urinary-Bladder Fibrosis and Telangiectasia Associated with Long-Term Cyclophosphamide Therapy

Authors:
  • WJWarren W. Johnson
    Warren W. Johnson
  • DMDavid C. Meadows
    David C. Meadows
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Abstract
Forty urinary bladders from patients treated with cyclophosphamide for neoplastic disease were examined at autopsy. Ten bladders were fibrotic; three also exhibited mucosal telangiectasia. The 10 were from patients who had received the largest quantities of the drug over the longest periods. Nine of the 10 had received the drug intravenously; the tenth had received it intravenously and orally. Five had gross hematuria, but five had been asymptomatic.