Determination of theophylline in plasma: comparison of high-performance liquid chromatography and an enzyme multiplied immunoassay technique

Authors:
  • MEM. L. Eppel
    M. L. Eppel
  • JOJ. S. Oliver
    J. S. Oliver
  • HSHamilton Smith
    Hamilton Smith
  • AMA. Mackay
    A. Mackay
  • LRL. E. Ramsay
    L. E. Ramsay
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Abstract
Plasma theophylline concentrations have been determined by both high-performance liquid chromatography and the enzyme multiplied immunoassay technique (EMIT). Comparison of the results showed a good correlation between the techniques. The faster processing time and smaller sample size makes EMIT the preferred technique when routine batch assays for theophylline are required.