Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs

Authors:
  • GKG. L. Kauffman
    G. L. Kauffman
  • DAD. Aures
    D. Aures
  • MGM. I. Grossman
    M. I. Grossman
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Abstract
The effect of 2 known inhibitors of prostaglandin [PG] synthesis, indomethacin and aspirin, on blood flow was studied in 6 Heidenhain pouch and 3 antral pouch dogs. The unstimulated gastric mucosa was bathed with 0.15 M HCl and clearance of [14C]-aminopyrine was used as an index of changes in mucosal blood flow. [14C]aminopyrine clearance was measured during three 15 min predrug periods and five 15 min post drug periods. Indomethacin (10 mg/kg) aspirin (100 mg/kg) or 0.15 M NaCl were given i.v. a bolus. Indomethacin reduced mucosal blood flow in the Heidenhain pouch 52% (P < 0.05). Aspirin reduced Heidenhain pouch mucosal blood flow 31% (P < 0.05). Indomethacin caused no significant change in electrical potential difference or in net flux of H+ or Na+ in Heidenhain pouches. Indomethacin (10 mg/kg i.v.) produced no change in mean arterial pressure. Indomethacin and aspirin reduced unstimulated gastric mucosal blood flow; apparently, endogenous PG may contribute to its maintenance.