Association of Mortality With Aortic Stenosis Severity in Outpatients

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  • VIVALVENOR Investigators
    VALVENOR Investigators
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Abstract
Five decades have passed since Ross and Braunwald1 described the natural history of aortic stenosis (AS). Although the clinical significance of severe AS has been consistently documented,2,3 a few recent studies suggest that less advanced stages of severity (mild and moderate AS) are also associated with poor prognosis, eg, increased mortality in patients with moderate AS without reaching the burden of severe AS.4-8 In 2019, Strange et al9 reported that survival in patients with moderate AS could be superimposable to that of severe AS. The question of more timely interventions in moderate as well as severe AS to improve outcomes emerges at a time of low morbidity and mortality from surgical and transcatheter aortic valve replacement (AVR).10 Importantly, previous studies dealing with the outcome of AS were based on limited data regarding the number of patients or lacked information regarding comorbid factors, modes of death, or progression in severity of AS.

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