Which way does the citric acid cycle turn during hypoxia? The critical role of α‐ketoglutarate dehydrogenase complex
- 1 February 2013
- journal article
- review article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 91 (8) , 1030-1043
Abstract
The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a “cycle”, during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high‐energy phosphates through matrix substrate‐level phosphorylation in the absence of oxidative phosphorylation. In this Mini‐Review, these segments are appraised, pointing to the critical importance of the α‐ketoglutarate dehydrogenase complex dictating their directionalities.Keywords
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