EFFECT OF DIFFERENT RATES OF INFUSION OF PROPOFOL FOR INDUCTION OF ANAESTHESIA IN ELDERLY PATIENTS

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Abstract
The effect of changing the rate of infusion of propofol for induction of anaestheia was studied in 60 elderly patients. Propofol was administered at 300, 600 or 1200 ml h−1 until loss of consciousness (as judged by loss of verbal contact with the patient) had been achieved. The duration of induction was significantly longer (P < 0.001) with the slower infusion rates (104, 68 and 51 s), but the total dose used was significantly less (P < 0.001) in these patients (1.2, 1.6 and 2.5 mg kg−1, respectively). The decrease in systolic and diastolic arterial pressure was significantly less in the 300-ml h−1 group at the end of induction and immediately after induction (P < 0.01). The incidence of apnoea was also significantly less in the slower infusion group.

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