Novel Chitosan–Riboflavin Conjugate with Visible Light-Enhanced Antifungal Properties against Penicillium digitatum

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Abstract
A novel chemical conjugate between chitosan (CH) and riboflavin (RF) has been synthesized and characterized via Fourier transform infrared, NMR, and other spectroscopic methods. Photophysical and photochemical properties such as absorption spectra, fluorescence emission, fluorescence anisotropy, and singlet oxygen generation were characterized as well. This new biopolymer-based conjugate was designed to have an antifungal effect enhanced through antimicrobial photodynamic therapy. The antifungal effect of this conjugate (CH–RF) was compared with CH and RF against Penicillium digitatum in vitro. The conjugate showed the highest fungal growth inhibition of all systems tested at a dose of 0.5% w/v. This new biopolymer-based compound could be a promising alternative to fungicides used in citrus fruits postharvest.
Funding Information
  • Direcci?n de Transferencia y Desarrollo, Pontificia Universidad Cat?lica de Chile
  • Facultad de Qu?mica y de Farmacia, Pontificia Universidad Cat?lica de Chile

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