Real-world platinum selection in immune checkpoint inhibitor-based therapy for recurrent or metastatic head and neck cancer: an exploratory multi-institutional retrospective study

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Abstract
The KEYNOTE-048 trial established pembrolizumab plus platinum and 5-fluorouracil (5-FU) as the standard first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). In the present study, the efficacy and safety of cisplatin and carboplatin in combination with pembrolizumab were compared using real-world data. In this retrospective study, 76 patients with R/M HNSCC treated with pembrolizumab plus 5-FU and either cisplatin (n = 41) or carboplatin (n = 35) were analysed. The primary endpoint was overall survival (OS); secondary endpoints included progression-free survival (PFS), objective response rate (ORR), and the incidence of grade ≥ 3 haematological and grade ≥ 2 non-haematological adverse events. The median PFS was 4.1 months with cisplatin and 7.1 months with carboplatin (p = 0.58). The median OS values were 14.8 and 20.7 months, respectively (p = 0.88). The ORR values were similar (34.1% vs. 34.3%, p = 0.99). Grade ≥ 3 haematological adverse events were more frequent with cisplatin than with carboplatin (87.8% vs. 48.6%, p < 0.01), as were grade ≥ 2 non-haematological adverse events (97.6% vs. 54.3%, p < 0.01). Cisplatin did not demonstrate a significant advantage over carboplatin in terms of OS, PFS, and ORR, but was associated with higher toxicity pembrolizumab-based therapy for R/M HNSCC. These findings suggest that carboplatin may represent a reasonable alternative in combination with pembrolizumab.

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