Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology
Authors:
- Bruna BizzarroBBBruna Bizzarro
- Michele S BarrosMBMichele S Barros
- Ceres MacielCMCeres Maciel
- Daniele I GueroniDGDaniele I Gueroni
- Ciro N LinoCLCiro N Lino
- Júlia CampopianoJCJúlia Campopiano
- Michalis KotsyfakisMichalis Kotsyfakis
- Gustavo P Amarante-MendesGustavo P Amarante-Mendes
- Eric CalvoECEric Calvo
- Margareth L CapurroMCMargareth L Capurro
- Anderson Sá-NunesASAnderson Sá-Nunes
Open Access
- 15 November 2013
- journal article
- research article
- Published by Springer Nature in Parasites & Vectors
- Vol. 6 (1) , 329
Abstract
Saliva is a key element of interaction between hematophagous mosquitoes and their vertebrate hosts. In addition to allowing a successful blood meal by neutralizing or delaying hemostatic responses, the salivary cocktail is also able to modulate the effector mechanisms of host immune responses facilitating, in turn, the transmission of several types of microorganisms. Understanding how the mosquito uses its salivary components to circumvent host immunity might help to clarify the mechanisms of transmission of such pathogens and disease establishment.Keywords
This publication has 49 references indexed in Scilit:
- Lufaxin, a Novel Factor Xa Inhibitor From the Salivary Gland of the Sand Fly Lutzomyia longipalpis Blocks Protease-Activated Receptor 2 Activation and Inhibits Inflammation and Thrombosis In VivoArteriosclerosis, Thrombosis, and Vascular Biology, 2012
- Association of human immune response to Aedes aegypti salivary proteins with dengue disease severityParasite Immunology, 2011
- Implication of haematophagous arthropod salivary proteins in host-vector interactionsParasites & Vectors, 2011
- Deconstructing Tick SalivaJournal of Biological Chemistry, 2011
- Mosquito Saliva Causes Enhancement of West Nile Virus Infection in MiceJournal of Virology, 2011
- Vascular and dendritic cell coagulation signaling in sepsis progressionJournal of Thrombosis and Haemostasis, 2009
- SAAG‐4 is a novel mosquito salivary protein that programmes host CD4+ T cells to express IL‐4Parasite Immunology, 2009
- The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune responseTransactions of the Royal Society of Tropical Medicine and Hygiene, 2008
- Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasisJournal of Experimental Medicine, 2007
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999