Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus

Authors:
  • OAOleg V. Ardashov
    Oleg V. Ardashov
  • VZVladimir V. Zarubaev
    Vladimir V. Zarubaev
  • ASAnna A. Shtro
    Anna A. Shtro
  • DKDina V. Korchagina
    Dina V. Korchagina
  • KVKonstantin P. Volcho
    Konstantin P. Volcho
  • NSNariman F. Salakhutdinov
    Nariman F. Salakhutdinov
  • OKOleg I. Kiselev
    Oleg I. Kiselev
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Abstract
A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.