Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway

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Abstract
Graphical In TNBC cells, the inhibition of C1QBP suppresses PKC–NF-κB signaling in cytoplasm, upregulating Iκβα expression, thereby decreasing the VCAM-1 expression by lowering p65 level in nucleus in normoxic conditions. When TNBC cells are exposed to hypoxic conditions, HIF-1α upregulates C1QBP expression. The inhibition of C1QBP notably suppresses the activation of hypoxia-induced PKC–NF-κB signaling and decreases VCAM-1 level, resulting in metastasis blocking and PTX drug chemoresistance decreasing of TNBC cells.

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