A correlation between protein thermostability and resistance to proteolysis
Authors:
- R M DanielRDR M Daniel
- D A CowanD A Cowan
- H W MorganHMH W Morgan
- M P CurranMCM P Curran
- 1 December 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 207 (3) , 641-644
Abstract
The loss of activity due to proteolysis of purified L-asparaginase and beta-galactosidase from different sources correlates with the thermal instability of the enzymes. A similar correlation is found when populations of soluble proteins from micro-organisms grown at different temperatures are compared for proteolytic susceptibility and thermal stability. It is proposed that there is a general correlation between the thermostability of proteins and their resistance to proteolysis.Keywords
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