Role of Toll‐like Receptors in HMGB1 Release from Macrophages
- 29 August 2007
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1109 (1) , 58-65
Abstract
HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll‐like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.Keywords
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