Imaging infection with LeuTech®

Authors:
  • CMC. S. Marcus
    C. S. Marcus
  • SKS. L. Kipper
    S. L. Kipper
  • RAR. Ahdoot
    R. Ahdoot
  • LDL. Diggles
    L. Diggles
  • HPH. L. Pham
    H. L. Pham
  • CMC. Minami
    C. Minami
  • BRB. A. Rhodes
    B. A. Rhodes
  • MPM. C. Patel
    M. C. Patel
  • TST. Smith
    T. Smith
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Abstract
LeuTech® is a 99Tcm labelled, anti-CD15, IgM, murine monoclonal antibody shown to have high affinity (K d = 10−11 M) for CD15 receptors (5.1×105/cell) expressed on human neutrophils. LeuTech® was injected directly, intravenously, and its efficacy in imaging infection in 46 consecutive patients was determined. Human anti-mouse antibody (HAMA) response was examined in 30 normal volunteers using a standard LeuTech® dose reconstituted with decayed 99Tcm solution. There were 38 true positive, six true negative, and two false negative scans. Of the 38 positive images, 33 (92%) were positive within 10 min after injection of LeuTech®. LeuTech® accuracy in this group of patients was 96%, sensitivity 95%, specificity 100%, positive predictive value (PPV) 100%, and negative predictive value (NPV) 75%. No elevation of the HAMA titre was observed in any of the 30 normal volunteers and no adverse reaction was noted in any patient. LeuTech® is a highly promising agent for rapid imaging of infectious foci.

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